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Patients experiencing acute pain after surgery, including dental surgery, often require analgesia. Ideally, the chosen analgesic should have a rapid onset and sustained effect. Etoricoxib is a new cyclooxygenaseselective inhibitor that has demonstrated analgesic efficacy in the treatment of acute pain with a rapid onset and long-lasting pain relief.
Robert (taken for 1 to 6 years) 21.02.2016
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This randomized double-blind study compared the analgesic efficacy and tolerability of etoricoxib versus ketoprofen in patients with elective total primary knee arthroplasty. The effectiveness was evaluated by the time from the initiation of spinal anesthesia until the first analgesic dose, the total amount of administered in the surgery day and the first postoperative day, and the frequency of patients with side effects and necessary amount of adjuvant medication. The baseline demographic characteristics were similar among the 3 groups.
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This non-approvable letter was due to safety concerns of an increased risk of cardiovascular events including heart attack and stroke and questions on the benefit-risk ratio in patients taking Arcoxia. Merck will continue to market Arcoxia outside the United States.
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