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Sections without translation will be in English. The morbidity and treatment costs associated with skin and soft tissue infections SSTIs are high. We included nine RCTs participants. Linezolid was associated with a https://www.pinnaclehealth.org significantly better clinical RR 1. There were fewer incidents of red man syndrome RR 0. The daily cost of outpatient therapy was less with oral linezolid than with intravenous vancomycin. Although inpatient treatment with linezolid cost more than inpatient treatment with vancomycin per day, the median length of hospital stay was three days shorter with linezolid. Thus, total hospital charges per patient were less with linezolid treatment than with vancomycin treatment. For serious skin and soft tissue infections involving the deeper tissues, the death rate and treatment costs are high.

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Language: English French. The cost implications of using intravenous and oral linezolid instead of intravenous vancomycin in Canadian clinical practice have not been examined. Health care resource use associated with linezolid and vancomycin therapy was estimated for patients in Quebec, based on expert opinion. Costs were assigned to health care resources antibiotics, medical supplies, laboratory testing and health care professional time based on unit prices. Therapy duration, length of inpatient treatment and discharge rates were varied in sensitivity analyses.

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