Improved treatment for onchocerciasis is needed to accelerate onchocerciasis elimination in Africa. Microfiladermia was determined pretreatment and at 6, 18, and 36 months. The primary outcome was the proportion of fertile and viable female worms in onchocercomata excised at 36 months. While the adult worms that develop from transmitted third-stage larvae L3 reside in subcutaneous nodules onchocercomata and do little harm, the microfilariae MF that are being released cause dermatitis when they reside in the skin and ocular lesions when they migrate into the eye. Several developments have greatly improved the onchocerciasis situation since the s. While IVM has good activity against MF, in the doses commonly used for onchocerciasis control programs it does not kill Onchocerca volvulus adult worms, which have a reproductive life span of 12—14 years.
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