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How does aspirin interact with ibuprofen? What are alternatives to ibuprofen? In, the US Food and Drug Administration FDA alerted healthcare professionals about the potential for ibuprofen to interfere with the antiplatelet effect of low-dose aspirin 81 mg daily. Consequently, irreversible inhibition of thromboxane B2 production by aspirin and inhibition of platelet aggregation may be reduced. Data are conflicting.

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